Bovine colostrum supplemented orally is known to support healthy human immunity. Healthy men cycled for 2 hours after receiving a daily colostrum for 4 weeks (in comparison to a control group) as done in a new study. There were no deficits in the front line immunity of those taking the colostrum, in contrast to those experienced by the group not taking colostrum.
Aerobic exercise may be good for overall health but it can weaken the immune system
Obtaining a decent response to aerobic exercise is vital for longevity and health. However, one problem is that exercise can diminish the front line of your immune system. This will be certainly relevant to those actively exercising during the winter bug season. This study reveals that daily ingesting colostrum can prevent a lowering of your immune system function.
Although this study was performed on healthy men, its value could be particularly important to individuals struggling with exercise, like those with fibromyalgia. In this scenario, exercise is crucial for improvement but performing exercise can be a problem and create a whole set of problems. It is probable that colostrum, which is a far-reaching powerhouse metabolically, would appear to be useful to aid in the response to exercise in such individuals.
Colostrum is formulated to support the requirements of the high growth phase in infants, a nutrient suited ideally for enhanced recovery and regeneration that goes with the process of fast growth. It appears that it fits in well as a support nutrient for rehabilitation from excess demands linked with physical performance. In this case it is proven in healthy men, but theoretically also aiding those who fight to get a good response to exercise (which is consonant with observations of the nutrient in clinical practice.)
Increased intakes of soy protein may reduce cholesterol levels in people with type-2 diabetes, says a new study that expands on the heart healthy potential of soy.
Consumption of 40 grams of soy protein isolate (SPI) per day for 57 days resulted in significant reductions in both LDL cholesterol and the ratio of LDL to HDL cholesterol, compared to consumption of the same dose of milk protein, according to results published in the Journal of Nutrition.
“This study provides evidence for soy as a dietary preventive strategy for adults with type-2 diabetes to reduce their cardiovascular disease risk and, in so doing, improve their quality, and possibly length, of life,” wrote the researchers, led by Alison Duncan from the University of Guelph.
The association between soy protein and blood lipid levels, led the Food and Drug Administration (FDA) to approve a cardiovascular disease (CVD) reduction claim for soybean protein in 1999.
Hypercholesterolaemia has a long association with many diseases, particularly cardiovascular disease (CVD), the cause of almost 50 per cent of deaths in Europe, and reported to cost the EU economy an estimated €169bn ($202bn) per year.
“This study therefore adds to the literature through its particular emphasis on prevention by studying adults with type-2 diabetes who are free of diabetic complications and not taking glycemic or lipid-lowering mediations,” wrote Duncan and her co-workers.
Dr Duncan and her co-workers recruited 29 type-2 diabetics for their double-blind, randomized, crossover, placebo-controlled intervention study. The participants were assigned to consume a daily dose of soy protein isolate, which also contained 80 mg of aglycone isoflavones, or milk protein isolate for 57 days. At the end of the intervention they underwent a 28 day washout period prior to being crossed over to the other intervention.
The soy (Supra Soy) and milk products used were provided by Solae.
According to their findings, the soy protein intervention was associated with a significant reduction in LDL cholesterol levels of 0.17 mmol/l, a reduction in the ratio of LDL to HDL cholesterol of 0.03 points, and drops in the ratio of apolipoprotein B:apolipoprotein A-I, compared to the milk protein intervention.
Apolipoprotein B is the main apolipoprotein of LDL cholesterol and is responsible for the transport of cholesterol to tissues. In high concentrations it has been linked to plaque formation in the blood vessels, although the mechanism behind this is not clear.
“The inclusion of apolipoproteins in future soy intervention studies is highly warranted; their relevance to CVD risk is well established and there is a particular emphasis on the apolipoprotein B:apolipoprotein A-I ratio as highly predictive in the evaluation of cardiac risk,” wrote the researchers.
The ratio of total cholesterol to HDL cholesterol, reported to be the most specific lipid risk factor for cardiovascular disease (CVD), was not affected by the intervention, they added.
No changes in HDL cholesterol were noted by the researchers.
“These data demonstrate that consumption of soy protein can modulate some serum lipids in a direction beneficial for CVD risk in adults with type 2 diabetes,” wrote the researchers.
Source : Journal of Nutrition
September 2009, Volume 139, Pages 1700-1706, doi:10.3945/jn.109.109595
“Soy Protein Reduces Serum LDL Cholesterol and the LDL Cholesterol:HDL Cholesterol and Apolipoprotein B:Apolipoprotein A-I Ratios in Adults with Type 2 Diabetes”
Authors: E.A. Pipe, C.P. Gobert, S.E. Capes, G.A. Darlington, J.W. Lampe, A.M. Duncan
(Orange, CA) October 9, 2009 – Naturade has announced it has introduced Alcohol-Free EXPEC,® an all natural, cherry flavored, non-drowsy, herbal alcohol-free expectorant, to its line of cough and cold remedies.
Alcohol Free EXPEC® is formulated with herbs and Guaifenesin, an all natural active ingredient derived from the Guaiac tree. Guaifenesin is a highly effective and safe expectorant that helps loosen mucus and clear bronchial passages.
Alcohol Free EXPEC®, available in 4.2 and 8.8 fluid ounces, will initially be distributed through health and natural food stores nationwide. Suggested retail price is $7.79 and $12.49 respectively.
Other Naturade expectorants include cherry flavored Herbal EXPEC®, Sugar Free EXPEC® and Children’s EXPEC®. The herbal cough and cold line also includes Naturade® Saline & Aloe Nasal Spray.
Headquartered in Orange, CA, Naturade is well-known for its commitment to improving the health and well-being of consumers with innovative, natural products since 1926. The company focuses on building consumer-recognizable brands backed by strong science and making them widely available through health food stores, natural supermarkets and other retail channels throughout the U.S.
Literature Review Finds No Indication that Soy Decreases Testosterone Levels
ST LOUIS, July 20 /PRNewswire/ — A new study published by the American Society for Reproductive Medicine finds that soyfoods and soy isoflavone supplements have no significant effect on male reproductive hormone levels in men. The literature review indicates that soy does not decrease testosterone levels.
Led by Jill M. Hamilton-Reeves, PhD, RD, of St. Catherine’s University, St. Paul, Minnesota, researchers assessed the effects of soy protein and soy isoflavones on measurements of male reproductive hormones. Findings, just published online in Fertility and Sterility, a publication of the American Society for Reproductive Medicine, demonstrate no significant effect of soy protein or soy isoflavone intake on circulating levels of testosterone, sex hormone-binding globulin or free testosterone in men.
The comprehensive meta-analysis examined the existing scientific literature including all clinical studies examining soy’s effect on male reproductive hormones published before July 1, 2008. Fifteen placebo-controlled treatment groups with baseline and ending measures were analyzed. Thirty-two reports involving 36 treatment groups were also assessed in simpler statistical models. Studies published after July 1, 2008, which were not included in the meta-analysis, support the conclusions of the meta-analysis.
Reproductive endocrinologist William R. Phipps, MD, of the University of Rochester Medical Center, a co-author of the analysis stated, “As a high-quality source of protein that is relatively low in saturated fat, soy can be an important part of a heart-healthy diet and may contribute to a decreased risk of coronary heart disease.” He noted that some men have been reluctant to consume soyfoods due to concerns about estrogen-like effects of soy isoflavones, often referred to as phytoestrogens. But according to Phipps, “it is important for the public to understand that there is no clinical evidence to support these ideas. After conducting a comprehensive review of the existing literature, we found no indication that soy significantly alters male sex hormone levels.”
Men can benefit from soyfood consumption as a means to meet daily protein requirements and at the same time possibly also reducing their risk of heart disease.
Citing the research study, Lisa Kelly, MPH, RD, of the United Soybean Board, added,
“Soy is often praised for the positive role it can play in the diets of women. But, years of clinical research have shown that men stand to benefit from soy, too. I encourage men to incorporate soyfoods into a balanced and varied diet and talk to their healthcare provider about their own unique nutritional needs.”
SOURCE: United Soybean Board
Orange, CA – Naturade is honored to have received a first place at the annual Vity Awards. The Vity Awards (The Oscars of the natural products industry) honor the industry’s top-selling products based on a nationwide survey of health food stores conducted by Vitamin Retailer Magazine.
Naturade® Weight Gain™ obtained first place for the weight gain category. Naturade® Weight Gain™ is an all-natural, nutrient dense food formulated to help magnify caloric intake and gain weight fast. It provides balanced nutrition with 10 grams of protein per serving plus no added sugar, no aspartame and no artificial ingredients of any kind. Bodybuilders and athletes enjoy Naturade® Weight Gain™ because they enhance the body’s utilization of nutrients for optimal calorie absorption. Naturade® Weight Gain™ is also recommended by doctors for therapeutic weight gain and recovery. In the gym, on the field, or on the road, Naturade® Weight Gain™ tastes great and is easy to prepare.
“We extend our sincere thanks to all the retailers who voted for our products. This affirmation of Naturade’s commitment to the highest quality standards is a tribute to the dedication and hard work of our entire team. At Naturade we continue to work at developing innovative new products and improving our existing formulas.” stated Naturade’s CEO Rick Robinette.
Headquartered in Orange, CA, Naturade Operating Corp. has been well-known for its commitment to improve the health and well-being of consumers with innovative, natural products since 1926. The company’s focus is on building consumer-recognizable brands backed by strong science and making them widely available through health food stores, natural supermarkets and retail channels throughout the U.S. including Whole Foods, Sprouts, Sam’s Club and Vitamin Shoppe. Its premier brand, Naturade®, is a line of protein powders for low carbohydrate dieters. Other Naturade® branded products include Total Soy® Meal Replacements, 100% WheyTM Protein Powders and Expec® Herbal Cough & Cold products. Other brands owned by Naturade Operating Corp. include Symbiotics Colostrum PlusTM, an immune strength product line and Ageless Foundation LaboratoriesTM, an anti-aging and rejuvenation line of products.
Naturade showcases Ageless Foundation anti-aging and rejuvenation supplements at Select Nutrition West show
On February 3rd 2009 Naturade attended Select Nutrition’s West Table Top Show in Universal City, CA. The event featured many national distributors of natural, organic and specialty foods. Select Nutrition a division of United Natural Foods, distributes more than 14,000 health and beauty aids, vitamins, minerals and supplements from distribution centers in California and Pennsylvania.
Kelli Clinton, Naturade’s Vice President of Sales comments:
“Since 1926 Naturade has taken the reigns as an innovator and provider of all natural health and beauty products all over the world and we are proud to support Select Nutrition. Our combined efforts demonstrate our commitment to the industry and to our customers by providing a wide range of products that improve consumer health.”
Demand for Anti-aging products in the health industry has grown exponentially. Industry experts have predicted that the growth for anti-aging products would be greater and increase from $20.4 billion in 2004 to $30.9 billion this year. In addition to its other lines Naturade has answered that call by featuring the new advanced Ageless Foundation line. Kelli Clinton:
“The Ageless Foundation line are the most advanced anti-aging formulas ever produced. These highly specialized formulas targets many areas of the body with cutting edge anti-aging nutrients and growth hormone releasers and is based upon numerous studies regarding safety and effectiveness. Ageless received a very warm welcome at the show. We are extremely proud of and look forward to our customers experiencing the benefits from this line.”
For more information about United Natural Foods’ shows & events, visit www.unfi.com
New research determines that dietary supplements rich in isoflavones may improve the function of arteries in stroke patients
A dietary supplement rich in isoflavones may improve the function of arteries in stroke patients, according to new research from Hong Kong.
The study is said to be the first randomized controlled trial investigating the effects of isoflavone supplements on improving the blood flow in the arm’s main artery in cardiovascular disease patients.
A daily 80 mg dose of isoflavones was associated with a one per cent increase in flow-mediated dilation (FMD), the measure of a blood vessel’s healthy ability to relax, according to findings published today in the European Heart Journal.
“Although the absolute increase in brachial diameter – one per cent – is small, the relative increase actually amounted to about 50 per cent because the mean average FMD in these stroke patients was about two per cent,” explained lead researcher Professor Hung-Fat Tse.
“These findings may have important implications for the use of isoflavone for secondary prevention in patients with cardiovascular disease, on top of conventional treatments,” wrote the authors in their EHJ paper.
Isoflavones from soy have been shown to provide a number of health benefits, including the promotion of heart health and the maintenance of bone health in post-menopausal women.
They have also been studied for their role in cancer prevention and slowing down the ageing process in peri-menopausal women, and isoflavone-rich supplements have proved to be a popular alternative to HRT for those wishing to control menopause symptoms without resorting to drugs.
Professor Tse and his co-workers from the University of Hong Kong recruited 102 stroke patients and randomly assigned 50 to receive daily isoflavone supplements (), and 52 to receive placebo, for 12 weeks.
“The specific dosage of 80 mg/day was chosen because previous studies have shown that isoflavone at this dosage was well tolerated by both men and women without significant side effects,” explained the researchers.
Ultrasound techniques were used to measure FMD at the start and end of the study. At the start, 80 per cent of the patients had an impaired FMD, defined as relaxation of less than 3.7 per cent. At the end of the 12 weeks, however, the patients receiving the isoflavone supplements experienced an improvement of one per cent, compared with the controls.
Moreover, the prevalence of impaired FMD after 12 weeks was only 58 per cent in the isoflavone group, compared to 79 per cent in the placebo group.
“The patients who had a lower initial FMD were found, in general, to respond with a larger absolute increase in FMD after receiving 12 weeks of isoflavone intervention, compared to patients who had a better baseline FMD in the first place,” said Prof Tse.
“These findings suggest that isoflavone reverses endothelial dysfunction in this group of patients with cardiovascular disease. This has important clinical implications, as the benefit of the [intervention] is conferred to the group of patients with the highest risks for cardiovascular events, and this effect persists, even at this rather late stage of the cardiovascular continuum.”
Supplementation with isoflavones was also associated with decreases in the levels of a protein called high-sensitivity C-reactive protein (CRP). This protein is a marker of inflammation and is reported to be an independent predictor of cardiovascular-related events.
“These findings suggested that isoflavone[s] alleviated vascular inflammatory stress and was an important component that mediated the reversal of endothelial dysfunction in this group of patients,” wrote the authors.
The mechanism by which the soy compounds is not totally understood, said Professor Tse. However, the anti-inflammatory effects may be related to the weak oestrogenic effect of the isoflavones. The female hormone oestrogen is known to protect against heart disease, said the researchers.
Despite the promising results of this clinical trial, the researchers stressed that it was too early to make any recommendations in this area.
“At this juncture, regular isoflavone supplement might not be advocated since the benefits and side effects of long-term supplementation are still unknown,” said Professor Tse.
“A balanced diet is still the top priority in promoting health. Diets with higher soy content might be beneficial due to the isoflavone contents. These food products also, in general, have higher contents of polyunsaturated fats, fibre, vitamins and less saturated fat.”
The immune system faces so many viruses, bacteria and other environmental threats throughout the year that it is getting more difficult to point to one season as needing the most attention. However, fall still showers its gold and red leaves on communities teeming with cold and flu viruses, as children return to school (read: infection incubators) and empty work offices return to full capacity with vacations mostly over. Consumers looking to bolster their defenses in early fall, in hopeful preparation for the coming cold and flu months, will turn to their trusty health products retailers for the latest offerings well-researched for immune benefits, especially relative to the dreaded cold season.
Whether in defense of the common cold, the flu or other challenges, empowering the immune system means increasing the production and strength of its white blood cells, such as T cells, macrophages and B cells. These cells coordinate a team effort to identify and destroy potentially dangerous invaders like influenza viruses and the collection of more than 200 rhinoviruses that can manifest as the common cold.
Outright prevention of these types of illnesses is considered an endless pursuit, scientifically, but a strong immune system heading into the typical cold and flu season could be the difference between getting one short, mild cold versus a couple lingering colds, or having insufferable symptoms from a cold or flu versus having few, if any, uncomfortable symptoms.
With a common cold, the most people generally hope for is to fight it off quickly and minimize the discomfort. In this case, consumers turn to dietary intervention—most often via supplements—to help fight infection before it happens, as opposed to over-the-counter (OTC) medications that don’t apply until after infection and symptoms rear their ugly heads. Advantage: supplements.
In the case of the flu, public health officials try to gauge which of the few influenza strains will be most prevalent in a given year and tailor the flu vaccine to this estimation. Some years this strategy works pretty well, but other times the guesses are wrong. In fact, the Centers for Disease Control and Prevention (CDC) reported this year’s flu vaccine was only about 44-percent effective, contributing to an elevated flu season. Barry Ritz, Ph.D., a nutritional immunologist at Drexel University, Philadelphia, tracks such data, in addition to his activities in the field of immune research. He noted on average, influenza virus infects 5 to 20 percent of the U.S. population annually, contributing to approximately 200,000 hospitalizations and 36,000 deaths, mostly among the elderly. Fortunately, nutritional immunology has generated positive results to counter such negative statistics. “My own research demonstrates that dietary interventions can have dramatic effects on the immune response to influenza infection,” he said.
In his study of how dietary supplements may affect the innate immune response to influenza infection, Ritz has focused on how bovine colostrum can potentially help stave off or manage flu infection.
Ritz explained colostrum provides antibodies that are important for establishing passive immunity in newborns; colostrum also contains numerous other compounds, such as bioactive peptides, that appear to enhance immunity even later in life. On specific research, he reported oral administration of bovine colostrum to neonatal and adult mice has been demonstrated to affect local intestinal immunity, including an increase in macrophage function and natural killer cells.1,2
“In my own research, in collaboration with La Belle Inc., I am working to determine if bovine colostrum supplementation may also result in systemic effects on innate immunity and increased resistance to influenza infection,” Ritz said.
It appears to be a good direction, as Italian researchers reported in 2007 that bovine colostrum, with its concoction of antibodies, vitamins, growth factors and other nutrients, represents an inexpensive therapeutic tool in prevention and treatment of several human microbial infections, including influenza.3
According to Ritz, consumers need to know that science supports bovine colostrum as an immune and intestinal health support supplement. In purchasing colostrum, he advised retailers and consumers to choose colostrum products that are produced in the United States, to assure the highest quality standards. “Depending on special needs, consider colostrum concentrates that are lactose- or casein-free,” he added.
An emerging immune force, colostrum has been studied alongside probiotics,4 which have a longer appearance in immune research and are beginning to take hold in the minds of educated consumers, thanks in large part to the growth of functional foods.
“More consumers are becoming aware that they help GI health,” confirmed Lia Peterson-Love, director of marketing for Sedona Labs and Nutri-Health Supplements. “I don’t think many people know that probiotics help support a healthy immune response.” She emphasized there is great science being done on probiotics, adding the immunomodulatory actions of probiotics are at the forefront of research.
In fact, Sedona Labs based its iFlora® Nasal Health multi-probiotic formula on 2003 clinical research in Switzerland that showed probiotics, taken orally, support a healthy immune response in the nasal mucus.5 The researchers concluded, “the ingestion of probiotics may enhance the immune barrier of the upper respiratory tract and therefore constitute a clinically preventive therapy.” The iFlora formula includes N-acetyl cysteine (NAC), a natural amino acid antioxidant that helps break up stagnant mucus, helping to support nasal and upper respiratory health.
“Although research showing that probiotics have an effect on the immune system was being published in the 1990’s … it takes awhile for consumer awareness and to catch up,” said Peterson-Love. “There is still much to be learned about probiotics and how they affect the immune system.”
1. Yoshioka Y, et al. “Oral administration of bovine colostrum stimulates intestinal intraepithelial lymphocytes to polarize Th1-type in mice.” Int Immunopharmacol 2005;5(3):581-90.
2. Perez-Cano FJ, et al. “Bovine whey protein concentrate supplementation modulates maturation of immune system in suckling rats.” Br J Nutr. 2007;98:Suppl 1:S80-4.
3. Biswas P et al. “Immunomodulatory effects of bovine colostrum in human peripheral blood mononuclear cells.” New Microbiol. 2007 Oct;30(4):447-54.
4. Wei H, et al. “Synergistic antidigestion effect of Lactobacillus rhamnosus and bovine colostrums in simulated gastrointestinal tract (in vitro).” Appl Microbiol Biotechnol 2007;75(2):427-34.
5. Gluck U and Glebbers JO. “Ingested probiotics reduce nasal colonization with pathogenic bacteria (Staphylococcus aureus, Streptococcus pneumoniae, and beta-hemolytic streptococci).” Am J Clin Nutr. 2003 Feb;77(2):517-20.
by Steve Myers via Natural Products Marketplace
Extracts of Horehound leaves and wild cherry bark cause apoptosis and cell growth suppression in cancer cells
Extracts of Horehound leaves and wild cherry bark cause apoptosis and cell growth suppression in human colorectal cancer cells according study published in national peer review medical journal, PubMed Central
The report shows that extracts of anti-inflammatory horehound leaves and wild cherry bark exhibit anti-proliferative activity in human colorectal cancer cells. Both horehound and wild cherry extracts cause suppression of cell growth as well as induction of apoptosis.
Our data show that anti-inflammatory M. vulgare (horehound) leaves and P. serotina (wild cherry) bark extracts have anti-proliferative activity in human colorectal cancer cells and the mechanisms may involve enhanced NAG-1 expression and/or down-regulation of ?-catenin signaling.
Published in final edited form as: Oncol Rep. 2006 January; 15(1): 275–281