The randomized, double blind, placebo controlled study tested sexual function, performance, and libido levels in 60 healthy men aged between 21 and 50 years over a 6 week period. The results showed Testofen, one of the key ingredients in Vitali-T-Aid, produced a significant positive change in all parameters of libido. These results were recently published in Phytotherapy Research, a monthly international journal for medicinal plant research (2011; DOI: 10.1002/ptr.3360).
Vitali-T-Aid component Testofen, a standardized Trigonellafoenum-graecum (Fenugreek) extract and mineral formulation, demonstrated a significant positive effect on physiological aspects of male libido and may assist to maintain normal healthy testosterone levels. Researchers Elizabeth Steels and Amanda Rao from Applied Science and Nutrition Pty Ltd and Luis Vitetta from The University of Queensland, Brisbane, Australia, recruited 60 healthy males aged between 25 and 52, without erectile dysfunction (ED) and randomized them to an oral dose (two tablets per day) of either 600 mg/d Testofen or a placebo for six weeks. The primary outcome measure was the DIS-SR (male) self-administered QOL total score and the four domain scores. The secondary outcome was specific quality of life parameters. The same 600mg dosage equals the amount of Testofen in one serving of Vitali-T-Aid. Each daily dose of Vitali-T-Aid also contains a proprietary Male Enhancement Blend of L-Arginine and beneficial herbs, such as Saw Palmetto, Astragalus, Tribulus and Asian Ginseng, to help support enhanced male health and well-being.
One of the key ingredients in Vitali-T-Aid demonstrated an overall positive effect on physiological aspects of libido. In particular, there was a significant increase in sexual arousal and orgasm. Testofen had a positive effect on QOL in self-reported satisfaction with muscle strength, energy and well-being, but did not have an effect on mood or sleep. Serum prolactin and testosterone levels remained within the reference range.
Vitali-T-Aid, a new supplement from Naturade, naturally increases free testosterone levels. In clinical studies on the key studied ingredient, Testofen, free testosterone levels in test subjects were shown to increase by over 98% along with exercise. Testofen acts like testosterone by binding to the testosterone receptor sites and creating testosterone-like activity in the body, thereby supporting healthy free testosterone levels. Studies show that Vitali-T-Aid by Naturade is a natural solution for increasing free testosterone levels and promoting healthy libido, immune function and muscle mass. Vitali-T-Aid natural testosterone booster can be purchased on http://www.vitalitaid.com.
Naturade®, a leading brand in the natural products channel for more than 84 years, is proud to announce the introduction of Vitali-T-Aid™, a drug-free natural testosterone booster.
Vitali-T-Aid™ is a natural solution for boosting free testosterone levels and increasing libido.* The all natural, key ingredient in Vitali-T-Aid™ was shown in two double-blind, placebo-controlled, human clinical studies to be a safe and effective way to significantly increase free testosterone levels and improve libido. Additional findings including improved muscle mass and energy levels.*
Vitali-T-Aid was formulated to help combat the negative symptoms of androgen (testosterone) decline in the aging male, or what some people call low testosterone. Most men start experiencing a decline in the both testosterone and free testosterone levels in their late 30s and these levels continue to decline by 1% – 3% per year thereafter. By age 60, 20% of men will have significantly lowered testosterone levels which may impact energy, mood, libido, muscle mass maintenance and bone density.
“The active ingredient in Vitali-T-Aid T-Aid™ was shown to increase free testosterone by and average of 98% in human clinical studies. Each daily dose of Vitali-T-Aid™ also contains a proprietary Male Enhancement Blend of L-Arginine and beneficial herbs, such as Saw Palmetto, Astragalus, Tribulus and Asian Ginseng, to help support enhanced male health and well-being.* Vitali-T-Aid™ by Naturade® is a natural solution for increasing free testosterone levels and promoting healthy libido, muscle mass and energy*. We are very proud to offer a science-based efficacious product that addresses a serious condition that millions of men suffer from,” said Rick Robinette, the CEO of Naturade.
Vitali-T-Aid™ is being launched with a multi-million dollar direct response television and print advertising campaign and is also available at www.vitalitaid.com
PUNE, India—Furostanol glycosides isolated from fenugreek (as Testofen®, form Gencor ) increased muscle mass in castrated rats without affecting testosterone levels, in a recent study published is Phytotherapy Research ( 24: 1482–1488 (2010). DOI: 10.1002/ptr.3129 ). This anabolic activity has the potential to aid men as they enter so-called male menopause.
Andropause is an old-age disease associated with the loss of libido, loss of muscle mass and associated with decreased testosterone production. As the male body ages, gonadal function slowly declines with a resulting drop in serum testosterone, which can lead to multiple clinical manifestations such as a decrease in bone mass, learning factions, erectile functions, muscle mass and strength. On the other hand, fat mass increases.
Fenugreek ( Trigonella foenum ) has long been used in the traditional Indian systems of medicine for the treatment of various ailments, including sexual health. Western medicine often looks to testosterone replacement to treat erectile dysfunction, which has been shown to compromise the overall quality of life, and increase depression, anxiety and loss of self-esteem. Erectile dysfunction may also signal underlying disease including diabetes, hypertension and cardiovascular disease (CVD). A potential risk of testosterone replacement therapy is an increase in the incidence of prostate cancer.
In the present investigation, Testofen at dose of 35 mg/kg/d significantly increased the weight of the levator ani muscle without increasing the blood urea nitrogen (BUN) similar to exogenous testosterone (10 mg/kg) treatment, indicating anabolic activity. Anabolic agents induce positive nitrogen balance in living organisms. Another bioassay for anabolic activity involves measurement of the increase in weight of the levator ani muscle. This measure correlates well with the nitrogen retention bioassay and the two are usually performed for the determination of anabolic activity.
This current study used Testofen, a furostanol glycoside fraction of Trigonella foenum-graecum , in immature castrated male Wistar rats to investigate anabolic and androgenic activity. The Indian researchers also investigate the effect of Testofen on testicular histology in non-castrated immature rats. Both the castrated and intact rats were divided into the following groups: (I) Control (distilled water), (II) Testofen at 10 mg/kg/d, (III) Testofen at 35 mg/kg/d, (IV) and testosterone (10 mg/kg bi-weekly) for four weeks. At the end of the study, blood was withdrawn, serum testosterone and BUN were measured. Animals were killed and reproductive organs were excised and weighed.
Testosterone increased the body weight of rats significantly (P<0.001) from 151.6 to 254.2 g (68.94 percent increase), whereas the weight of 35-mg/kg-Testofen-treated rats was increased from 151.6 to 193.8 g (28 percent increase). The increase in body weight of 10-mg/kg-Testofen-treated rats was not significant compared with the control group.
Testosterone significantly increased the seminal vesicle, ventral prostate and levator ani weight, but not the penis weight. Testofen at 35 mg/kg, on the other hand, significantly (P<0.001) increased the weights of the levator ani muscle, but failed to increase other organ weights. At the lower dose of 10 mg/kg, Testofen did not increase organ weights.
Testofen at both doses did not change the testosterone level in either the castrated or intact rats, whereas testosterone treatment caused significant (P<0.001) increases in serum testosterone level.
The BUN in castrated rats was 33.44 mg/dL in the control group. The BUN was found to be 18.8 mg/dL in both the higher dose of Testofen and testosterone treatment groups. However, the lower dose of Testofen did not cause a significant change in BUN compared with the control group.
It is postulated that testosterone that is converted peripherally to dihydrotestosterone (DHT) by 5-alpha reductase is responsible for the prostate risk associated with testosterone therapy. DHT has a role in the growth of prostatic tissue and therefore can influence lower urinary tract symptoms. Endogenous testosterone in the circulation can be free (unbound), weakly bound to albumin, or tightly bound to sex hormone binding globulin (SHBG). The free and albumin-bound testosterone is available for use by the body. The largest percentage, however, is bound to SHBG and is unavailable for use in the body.
The results obtained in the present study showed that fenugreek furostanol glycoside possessed anabolic activity (increased muscle mass) without affecting total serum testosterone levels in castrated rats. The probable mechanism for this action may be due to increased availability of testosterone by dissociating it from the stored form, i.e., SHBG.