In the Pink Month or National Breast Cancer Awareness Month, the following is intended for breast cancer survivors.
A study published in Journal of American Medical Association suggests use of soy foods may help women diagnosed with breast cancer reduce risk of premature death and recurrence.
The study led by Shu X.O. and colleagues from Vanderbilt Epidemiology Center showed those who had highest intake of soy protein were 30 percent less likely to die or had recurrence of the disease during a 4-year follow-up.
Soy foods are high in isoflavones, phytoestrogens that have been associated with reduced risk of breast cancer in previous studies, according to the background information in the study report.
The study was meant to examine the effect of soy protein intake on the health in women who have already been diagnosed with breast cancer.
For the study, the researchers enlisted 5,042 female breast cancer survivors in China ages 20 to 75 years who participated in the Shanghai Breast Cancer Survival Study. The participants were diagnosed with the disease between March 2002 and April 2006 and followed up through June 2009.
During the 3.9-year follow-up, of 5,033 women who underwent surgery, 444 women died and 534 suffered recurrence or breast cancer related deaths.
The researchers found those who had highest intake of soy protein were 29 percent less likely to die and 32 percent less likely to have recurrence of breast cancer compared to those who had lowest intake.
The mortality rate among women having the highest intake of soy protein was 7.4 percent compared to 10.3 percent for those who had lowest intake.
The recurrence rate among those who ate highest amounts of soy foods was 8 percent compared to 11.2 percent among those who had the lowest intake.
The researchers concluded “Among women with breast cancer, soy food consumption was significantly associated with decreased risk of death and recurrence.”
More reports on diet and breast cancer will be released in the pink month.
New studies indicate that breast cancer survival rate may be increased with moderate soy consumption
Eating soy boosts breast cancer survival
Soy consumption for cancer patients has been the subject of some controversy. A new study has shown that breast cancer survivors who consume soy foods reap important health benefits and found that eating soy can increase the rate of survival for breast cancer patients.
According to a recent report published in the Journal of the American Medical Association (JAMA), women diagnosed with breast cancer and who consumed soy foods, such as tofu, soy milk, or edamame reduced their risk of recurrence by 32 percent. 1
Previous research refuted
Previous research had produced contradictory results with some studies suggesting that soy foods reduce the risk of breast cancer and others that compounds unique to soy may help breast cancer cells to grow. Now, previous theories been refuted with this new study demonstrating that soy does not increase the growth of breast cancer cells and has been proven to increase survival rates.
Higher soy intake – lower mortality
Researchers also found that breast cancer patients who consumed soy had a 29 percent decreased risk of death, compared to women who consumed little or no soy. Xiao Ou Shu, MD, PhD, lead researcher and professor of medicine at Vanderbilt University Medical Center in Nashville, TN, said, “Women who had a higher soy intake had a lower mortality and lower risk of relapse [than women with a low soy intake].”
Dr. Shu and her fellow researchers analyzed data from the Shanghai Breast Cancer Survival Study, the largest population-based study of breast cancer survival to date. The study included 5,042 women from 20 to 75 years of age and followed them for a period of four years.
Soy compounds reduce estrogen in the body
Soybeans are rich in phytoestrogens, also known as isoflavones. Although these substances are one thousand times less potent than human estrogen, there has been some concern that isoflavones may have an estrogen-like effect and may increase cancer risk.
However, many experts believe that because isoflavones fool the body into accepting the very weak compound, phytoestrogen actually competes with the human estrogen, thus reducing the overall level of estrogen in the body.
Soy is safe and potentially beneficial
An editorial accompanying this new study suggests some probable inconsistencies in prior research. The editorial attributed those inconsistencies to the fact that soy consumption in the U.S. is a good deal lower, which made the beneficial effects of consuming soy foods difficult to identify. In China, soy intake is higher and diets tend to include the intake of more traditional soy from food sources, rather than from soy supplements.
The researchers report, “The inverse association was evident among women with either estrogen receptor-positive or receptor-negative breast cancer and was present in both users and nonusers of tamoxifen.”
“In summary, in this population-based prospective study, we found that soy food intake is safe and was associated with lower mortality and recurrence among breast cancer patients.” These scientists concluded that, among women with breast cancer, soy food consumption was significantly associated with decreased risk of death and recurrence. Dr Shu and her colleagues stated, “This study suggests that moderate soy food intake is safe and potentially beneficial for women with breast cancer.”
1. Shu XO, Zheng Y, Cai H, et al. Soy food intake and breast cancer survival. JAMA. 2009;302:2437-2443. Ballard-Barbash R, Neuhouser ML. Challenges in design and interpretation of observational research on health behaviors and cancer survival. JAMA. 2009;302:2483-2484.